Editorial
Need for large scale randomised evidence about lowering LDL cholesterol in people with diabetes mellitus: MRC/BHF heart protection study and other major trials
| The first 150 words of the full text of this article appear below. |
Diabetes
mellitus contributes substantially to the global burden of disease,
with an estimated 100 million people affected worldwide, and its
prevalence is increasing rapidly.1 Macrovascular complications are among the chief causes of major morbidity in people
with diabetes, and most of their deaths are attributed to
cardiovascular causes.2 3 In type 2 ("non-insulin
dependent") diabetes, blood triglyceride concentrations tend to be
raised and high density lipoprotein (HDL) cholesterol concentrations reduced even with good metabolic control, whereas a similar pattern tends to emerge in type 1 ("insulin dependent") diabetes mellitus only when glycaemic control is poor.4 5 Typically in both type 1 and type 2 diabetes, however, blood concentrations of total and
low density lipoprotein (LDL) cholesterol are similar to those in the
general population. This may have contributed to the belief that LDL
cholesterol is of little relevance to the risk of cardiovascular disease in diabetes4 6 and, apart from those with
pronounced dyslipidaemia or pre-existing coronary heart
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Hobbs, F.D.R.
(2004). Guidelines and management of global risk: the European perspective. Eur Heart J Suppl
6: C5-C14
[Abstract] [Full Text] -
Betteridge, D.J.
(2004). Treating dyslipidaemia in the patient with type 2 diabetes. Eur Heart J Suppl
6: C28-C33
[Abstract] [Full Text] -
Prisant, L. M.
(2004). Clinical Trials and Lipid Guidelines for Type II Diabetes. J Clin Pharmacol
44: 423-430
[Abstract] [Full Text] -
Wright, S. P., Doughty, R. N., Pearl, A., Gamble, G. D., Whalley, G. A., Walsh, H. J., Gordon, G., Bagg, W., Oxenham, H., Yandle, T., Richards, M., Sharpe, N.
(2003). Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care: A randomized, controlled trial. J Am Coll Cardiol
42: 1793-1800
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
