Editorial
Cellular cardiomyoplasty: a new hope in heart failure?
| The first 150 words of the full text of this article appear below. |
Despite
recent advances in the management of patients with heart failure, and
because of the scarcity of heart donors, the incidence and prevalence
of the disease remains notably high in our countries. Recent
epidemiological data have shown an incidence of 225 patients with
severe heart failure per million, with a rate of death of 35% per
year.1 This has encouraged the development of new methods
of biological assistance, also called cardiomyoplasty techniques. The
first of these is dynamic cardiomyoplasty, which uses the latissimus
dorsi muscle wrapped around a deficient heart which is stimulated, but
this procedure produces inconsistent and moderate objective
haemodynamic effects. Another technique is molecular cardiomyoplasty,
which is based on the transformation of non-myogenic into contractile
cells or attempts to induce the cardiomyocytes to re-enter the cellular
cycle; for the moment this remains out of reach. A third technique is
cellular cardiomyoplasty, which involves myogenic cell grafting within
the
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