Heart 2000;84:579-581 ( December )

Editorial

Multisite stimulation for correction of cardiac asynchrony

The first 150 words of the full text of this article appear below.

Cardiac electrical stimulation as primary or adjunctive treatment of congestive heart failure is entering its second decade of existence. Initial trials of conventional DDD pacing^1-5 were followed by bifocal right ventricular stimulation.⁶ The concept of multisite stimulation for haemodynamic support was introduced in 1994.^7 8 Various studies have already reported the benefits of this method,^9 10 or are in progress.¹¹

The transition from conventional DDD pacing to multisite stimulation was not fortuitous. Successive "advances" in the design of cardiac pacing systems have aimed at correcting anomalies in the sequence of cardiac chamber activation, as well as in the synchronisation of the various phases of myocardial contraction and relaxation. The phenomenon of asynchrony is a consequence of progressive, global or focal degradation of the myocardium. One can easily visualise interstitial fibrosis gradually replacing areas of normal myocardium, and causing heterogeneous propagation of cardiac electrical activity. Such heterogeneity combines, to various degrees, three consecutive . . . [Full text of this article]

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