Heart 2000;84:587-594 ( December )

Review

Hibernating myocardium

R Schulz, G Heusch

Department of Pathophysiology, Centre of Internal Medicine, University of Essen, School of Medicine, Hufelandstrasse 55, 45122 Essen, Germany

Correspondence to: Prof Dr Gerd Heusch gerd.heusch@uni-essen.de

Accepted 16 August 2000

The first 150 words of the full text of this article appear below.

	Introduction

In 1973 Chatterjee and colleagues, on the basis of clinical observations, suggested that a "marked improvement and even normalisation of left ventricular function can be expected in properly selected patients with the preinfarction syndrome or with chronic ischaemia and no previous infarct, following appropriate aortocoronary artery bypass surgery".¹ Five years later Diamond and associates were the first to use the word "hibernation" in the introduction to an experimental study on postextrasystolic potentiation in ischaemic dog myocardium.² Somewhat vaguely, they concluded from the "sometimes dramatic improvement in segmental left ventricular function following coronary bypass surgery" that "ischaemic non-infarcted myocardium can exist in a state of function hibernation." In the early 1980s, Rahimtoola systematically reviewed the results of coronary bypass surgery trials and identified patients with coronary artery disease in whom chronic left ventricular dysfunction improved on revascularisation.^3 4 He then specified the term "hibernation" previously used by Diamond and associates, and proposed that . . . [Full text of this article]

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