Heart 2001;85:92-93 ( January )

Scientific letters

Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement

The first 150 words of the full text of this article appear below.

Following coronary stent placement, platelet activation is a major determinant of the risk of subacute stent thrombosis.¹ Combined antiplatelet treatment with ticlopidine and aspirin reduced platelet activation after coronary stenting¹. Although combined antiplatelet treatment consisting of aspirin and ticlopidine has significantly reduced early ischaemic events following coronary stenting, stent thrombosis still occurs in up to 1% of treated patients, especially in the early days after the intervention, probably because of delayed onset of action of ticlopidine. Clopidogrel is a ticlopidine-like novel thienopyridine inhibitor of ADP induced platelet activation.² Clopidogrel differs from ticlopidine in that it has a favourable safety profile compared to ticlopidine and reveals an accelerated antiplatelet activity after first administration. The present study sought to investigate the antiplatelet effect of various doses of clopidogrel in patients undergoing coronary stent placement; comparison was made with standard ticlopidine treatment.

Thirty patients were randomised into three treatment arms: group I . . . [Full text of this article]

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