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Heart 2001;85:601-602; doi:10.1136/heart.85.6.601
Copyright © 2001 BMJ Publishing Group Ltd & British Cardiovascular Society
Heart 2001;85:601-602 ( June )

Editorial

Why is there discordance between calcific aortic stenosis and coronary artery disease?

The first 150 words of the full text of this article appear below.

There are many similarities in the disease processes of calcific aortic stenosis and coronary artery disease. Both increase in prevalence with age, but neither is thought to be a normal consequence of aging. Calcific aortic stenosis is present in 2-3% of adults over age 65 years and irregular aortic valve thickening without obstruction to left ventricular outflow (aortic sclerosis) is present in about 25% of elderly adults.1 2 The presence of an abnormal aortic valve on echocardiography is associated with the same clinical factors, at a similar level of risk, as have been associated with coronary artery disease. Specifically, older age, male sex, increased serum low density lipoprotein (LDL) and Lp(a) lipoprotein concentrations, smoking, hypertension, and diabetes are associated with calcific aortic valve disease.1 3-5

Calcific aortic valve disease, ranging in severity from sclerosis to stenosis, is characterised by irregular areas of increased thickening on the aortic side of the valve. Grossly, these . . . [Full text of this article]
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