Editorial
Markers of inflammation in unstable angina
| The first 150 words of the full text of this article appear below. |
Atherosclerosis can be seen as a dynamic chronic inflammatory process, in which flares of inflammatory and thrombotic activity underlie the clinical presentations of unstable angina and myocardial infarction.1 2 In this issue of Heart, two articles draw attention to the inflammatory basis of acute coronary syndromes (ACS).
More evidence for circulating activated leucocytesThe first study, by Hillis and colleagues,3
focuses on expression and function of the 
2 integrin
CD11b/CD18 (Mac-1, CR3). The 2 integrins are a family of
four heterodimers, in which separate 
chains (CD11a-d) combine with
a common chain (CD18). CD11b/CD18 (Mac-1, CR3) is critical for
leucocyte adhesion and migration, and also acts as a receptor for
complement C3bi. In addition, CD11b/CD18 is a signalling molecule and
is necessary for many other neutrophil and monocyte effector functions
in inflammation.4 Both neutrophils and monocytes normally
carry CD11b/CD18 on the cell surface, and also contain additional
stores of the heterodimer in the
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This article has been cited by other articles:
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Saravanan, P., Exley, A. R., Valchanov, K., Casey, N. D., Falter, F.
(2009). Impact of xenon anaesthesia in isolated cardiopulmonary bypass on very early leucocyte and platelet activation and clearance: a randomized, controlled study. Br J Anaesth
103: 805-810
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