Editorial
How will the human genome project change cardiovascular medicine?
| The first 150 words of the full text of this article appear below. |
Cardiovascular disorders represent a major public health concern because of their high prevalence, morbidity, and mortality. Indeed hypertension, coronary artery disease, heart failure, stroke or peripheral vascular diseases are a major contributor to mortality and, because of the increase in life expectancy and aging, a pandemic both in developed and developing countries. The completion of the first working draft of the human DNA sequence,1 which was recently published, is considered by the international community as a major scientific contribution of the human genome project (HGP), an unprecedented international collaborative programme. How the HGP will affect cardiovascular medicine is therefore a question of paramount importance because of the socioeconomic impact of these disorders.
PromisesHuman DNA sequencing opens the door wide on promising perspectives in cardiovascular genetics.
NEW MORBID GENES AND VARIANTS
Although positional cloning has allowed major breakthroughs in the
understanding of the genetic background of various familial and often
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