Editorial
Angiographic assessment of myocardial perfusion: TIMI myocardial perfusion (TMP) grading system
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Since the introduction of reperfusion therapy in the early 1980s, cardiologists have largely focused on coronary artery flow and diameter, with the goal being to restore normal epicardial artery perfusion and large lumens. For many years, epicardial coronary flow has been simply assessed by the TIMI (thrombolysis in myocardial infarction) flow grade.1 This semiquantitative coronary angiographic tool places a patient's coronary flow into one of four different categories and has been shown to be associated with mortality. The corrected TIMI frame count provides a more objective quantitative index of coronary flow and has been shown to segregate even TIMI grade 3 flow into lower and higher risk subgroups.2-4
It is becoming increasingly clear that tissue perfusion, not just
an open artery, is critical to myocardial salvage. For instance, among
all patients with "open arteries" (TIMI grade 2 or 3), those with
TIMI 2 flow have a higher mortality, probably as a result of
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This article has been cited by other articles:
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KAUL, S.
(2001). Coronary angiography cannot be used to assess myocardial perfusion in patients undergoing reperfusion for acute myocardial infarction. Heart
86: 483-484
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