Review
Photodynamic therapy: shedding light on restenosis
R Mansfielda, S Bownb, J McEwanaa Cardiovascular
Repair and Remodelling Group, The Hatter Institute, Royal Free and UCL
Medical School, Middlesex Hospital, Mortimer Street, London W1N
8AA, UK, b National Medical Laser Centre, Royal Free and
UCL Medical School
Correspondence to: Dr Mansfield r.mansfield@ucl.ac.uk
Accepted 25 June
2001
| The first 150 words of the full text of this article appear below. |
 |
Introduction |
|---|
The
major limitation of the long term success of percutaneous coronary
interventions is the development of restenosis, which occurs in
30-50% of patients within six months.1 2 Restenosis is
the result of a complex pathophysiological process in the arterial wall
in response to balloon dilatation or stent insertion. For many years
the hallmark of this response to injury was considered to be the
development of intimal hyperplasia resulting from the proliferation and
migration of smooth muscle cells from the arterial media.3
More recently, it has become clear that this is not the only factor
involved. Other key aspects in the development of the restenotic lesion
are the extracellular matrix, elastic vessel recoil, and arterial
remodelling.4 While our understanding of the processes
induced by balloon injury has improved, treatment strategies to limit
this have been disappointing in clinical practice.5 Stenting, which is now used in up to 80% of all coronary
interventional
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