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Toronto General Hospital, University Health Network
and University of Toronto, Toronto, Ontario,
Canada
Correspondence to: E Douglas Wigle MD, Department of Medicine (Cardiology), Toronto General Hospital, 200 Elizabeth Street, 12-EN-217, Toronto, Ontario M5G 2C4, Canada
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Although
the pathology of hypertrophic cardiomyopathy (HCM) was first described
by French pathologists in the mid 19th century, it remained for the
virtually simultaneous reports of Brock and Teare in England some 43 years ago to bring modern attention to this fascinating
entity.1 2 Subsequent to these surgical1 and
pathological2 observations, there has been an almost
exponential growth in the number of research reports and in our
knowledge of HCM, and a number of extensive reviews have been
published.3-9 HCM was initially thought to be relatively
rare, but it is now recognised to be an important cause of morbidity
and mortality in people of all ages. In tertiary referral populations
the annual mortality is 3-4% per annum (higher in the young) and
1-2% per annum in non-referred populations. It occurs in 1 in 500 live births, making it as common as cystic fibrosis, and is the most common cause of sudden death during athletic
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