© 2002 by Heart
EDUCATION IN HEART
Basic science
Myocardial molecular biology: an introduction
Correspondence to:
Correspondence to:
Dr Nigel J Brand, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science Technology and Medicine, Dovehouse Street, London, SW3 6LY, UK;
n.brand@ic.ac.uk
Keywords: gene regulation; gene expression; molecular biology
The recent publication of draft copies of the human genome sequence from both public and private sector consortia has fuelled anticipation that eventually, once all genes have been identified, we will be able to ascertain which of them are involved in human diseases, including those affecting the cardiovascular system. Understanding the molecular biology behind both inherited and acquired disorders is now viewed as essential to provide a full picture of the aetiology and progression of disease. Within the past decade considerable advances have been made in identifying the genetic basis of myocardial disorders such as familial hypertrophic cardiomyopathy and dilated cardiomyopathy, as well as the molecular signalling pathways and gene regulatory events that characterise acquired disease such as pressure overload induced cardiac hypertrophy. Furthermore, by defining the molecular processes underlying normal development we may be able to manipulate immature cell phenotypes such as those of embryonic stem cells
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Heart 2002 87: 471.
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