© 2002 by Heart
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Ischaemic heart disease
Folate as a way to reduce in-stent restenosis 
Plasma homocysteine has been recognised as an important cardiovascular risk factor. Several groups have found a link between homocysteine concentrations and angiographic restenosis within stents. A trial of 553 patients assigned to lowering of homocysteine with B12 (400 µg/day), folate (1 mg/day), and pyridoxine (10 mg/day) versus placebo suggests benefit at one year. The combined end point of death/myocardial infarction/repeat revascularisation showed a relative risk (RR) of 0.68 on treatment (15.4% v 22.8%; p = 0.03), primarily caused by a reduced rate of target lesion revascularisation (9.9% v 16.0%, RR 0.62, 95% confidence interval (CI) 0.40 to 0.97; p = 0.03).
Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM. Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss heart study: a randomized controlled trial. JAMA 2002;
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