© 2002 by Heart
Degenerative mitral valve disease with emphasis on mitral valve prolapse
1 St George’s Hospital Medical School, London, UK
2 Institut Mutualiste Monsouris, Paris, France
Correspondence to:
Correspondence to:
Dr Denis Pellerin, St George’s Hospital Medical School, Blackshaw Road, London SW17 0QT, UK;
dpelleri@sghms.ac.uk
Keywords: degenerative mitral valve disease; mitral valve prolapse; transoesophageal echocardiography; transthoracic echocardiography
Abbreviations: LV, left ventricular; MVP, mitral valve prolapse; NYHA, New York Heart Association; TOE, transoesophageal echocardiography; TTE, transthoracic echocardiography
| The first 150 words of the full text of this article appear below. |
Degenerative mitral valve disease is responsible for the syndromes of billowing mitral leaflet, mitral valve prolapse (MVP), floppy mitral valve, and flail leaflet.1–6 The pathology of these is mainly caused by myxomatous infiltration and fibroelastic deficiency.
In the 1960s, Reid7 and Barlow and colleagues1 proposed that mid to late systolic clicks and apical late systolic murmurs were of mitral valvar origin. This origin was further documented by intracardiac phonocardiography.8 Criley and colleagues used "mitral valve prolapse" to describe posterior mitral leaflet motion in systole.9 Since then, MVP has remained a diagnosis of sustained interest and controversy.
Because MVP is asymptomatic or has a non-specific clinical presentation, the disease is often detected by the non-ejection systolic click of the mitral valve and the late systolic murmur. MVP is clinically benign with potential for serious complications in otherwise healthy people, such as degenerative mitral regurgitation and infective endocarditis. Age and sex distributions
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