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Assessment of myocardial viability: using coronary pressure and flow after acute myocardial infarction

M J Kern

Correspondence to:
Correspondence to:
Morton J Kern, MD, J Gerard Mudd Cardiac Catheterization Laboratory, St Louis University Health Sciences Center, 3635 Vista Avenue at Grand Blvd, PO Box 15250, St Louis, MO 63110-0250, USA;
kernm@slu.edu

Keywords: myocardial viability; acute myocardial infarction

Abbreviations: CFR, coronary flow reserve; FDG, 18-fluoro-deoxyglucose; LV, left ventricular; PET, positron emission tomography; SIFP, slope index of the flow–pressure relation

The first 150 words of the full text of this article appear below.

Assessment of myocardial viability has been a challenge for revascularisation therapeutics in determining the effectiveness of an intervention and patient prognosis. In most cases, the current standard for viability is the recovery of function measured by left ventricular (LV) wall motion and the metabolic activity measured by positron emission tomography (PET) with the uptake of the metabolic tracer 18-fluoro-deoxyglucose (FDG). In this issue of Heart, Schimada and colleagues¹ report how they coupled this imaging methodology of the metabolic activity of viable myocardium with other physiologic indices. In 27 patients, coronary flow and pressure were measured after successful angioplasty in patients undergoing acute myocardial infarction intervention within 12 hours of the onset of symptoms. FDG PET scan results and pressure at zero flow slope index, the SIFP, from simultaneously recorded aortic pressure and coronary flow velocity signals at peak hyperaemia, distal to the lesion in the re-canalised artery were compared. . . . [Full text of this article]

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