© 2003 by BMJ Publishing Group & British Cardiac Society
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Ischaemic heart disease
One hundred and sixty patients with type 2 diabetes and microalbuminuria were randomly assigned to receive conventional care or intensive treatment. Patients in the intensive therapy group were treated with drugs to maintain glycosylated haemoglobin values below 6.5%, blood pressure below 130/80 mm Hg, cholesterol below 4.5 mmol/l, and triglyceride below 1.7 mmol/l. Recommended lifestyle interventions included reduced dietary fat, regular moderate exercise, and cessation of smoking. All participants in the intensive therapy group were also advised to take aspirin and a dietary supplement that included vitamins E and C, folic acid, and chrome picolinate. In addition, patients in the intensive therapy group were given an angiotensin converting enzyme (ACE) inhibitor (or, if contraindicated, an angiotensin II receptor antagonist), regardless of blood pressure, to slow the progression of renal disease. After a mean follow up of 7.8 years, one or more cardiovascular events (death from cardiovascular causes, non-fatal myocardial infarction
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