© 2003 by BMJ Publishing Group & British Cardiac Society
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Ischaemic heart disease
Angiographically complex plaques have more inflammation 
Previous work has shown that complex plaques are found in acute coronary syndromes (ACS) more often than in stable angina, and that inflammation plays a role in ACS. This study links the two findings. A total of 79 patients with unstable (n = 46) or stable angina (n = 33) underwent directional coronary atherectomy for culprit lesions. The mean (SD) percentage of macrophages in atherectomy specimens from patients with unstable angina was greater than in specimens from patients with stable angina (21 (14)% v 13 (10)%, p = 0.01); similar results were seen when complex coronary lesions were compared with simple lesions (23 (13)% v 9 (8)%, p < 0.001).
Meuwissen M, van der Wal AC, Koch KT, van der Loos CM, Chamuleau SAJ, Teeling P, de Winter RJ, Tijssen JGP, Becker AE, Piek JJ. Association between complex coronary artery stenosis and unstable
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