© 2004 by BMJ Publishing Group & British Cardiac Society
SCIENTIFIC LETTER
Circulating malondialdehyde modified LDL is a biochemical risk marker for coronary artery disease
1 Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan
2 SRL Inc, Tokyo, Japan
Correspondence to:
Correspondence to:
Dr T Suzuki
Department of Cardiovascular Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; torusuzu-tky@umin.ac.jp
Accepted 19 January 2004
Abbreviations: ACS, acute coronary syndromes; CAD, coronary artery disease; HDL, high density lipoprotein; LDL, low density lipoprotein; MDA, malondialdehyde-modified; Ox, oxidative; SVD, single vessel disease; 2VD, two vessel disease; 3VD, three vessel disease
Keywords: oxidised low density lipoprotein; coronary artery disease; risk marker
| The first 150 words of the full text of this article appear below. |
Oxidatively modified low density lipoprotein (OxLDL) plays an important role in the development of atherosclerosis as its uptake by macrophages and smooth muscle cells leads to formation of foam cells which is a critical step in the evolution of the pathological state.1,2 Circulating OxLDL concentrations may therefore reflect the state of pathological atherosclerosis, and be a possible biochemical risk marker for coronary artery disease (CAD). Numerous efforts have been directed at detecting OxLDL concentrations in the circulation for this reason, but technical difficulties have hampered detection of minute amounts of OxLDL. To overcome these limitations, we focused on circulating malondialdehyde modified LDL (MDA-LDL), a chemical modification thought to reflect naturally occurring oxidation of LDL,3,4 and developed a sensitive immunoassay of circulating MDA-LDL concentrations. The diagnostic performance of MDA-LDL in CAD was compared against known lipid markers. This comparison revealed, for the first time, that MDA-LDL is superior, thus suggesting that
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