© 2004 by BMJ Publishing Group & British Cardiac Society
EDITORIAL
Methotrexate eluting stents: to modify or cure?
Cardiovascular Research Group, University of Sheffield, Sheffield, UK
Correspondence to:
Correspondence to:
Dr Julian Gunn
Cardiovascular Research Group, Clinical Sciences Building, Northern General Hospital, Sheffield S5 7AU, UK; J.Gunn@Sheffield.ac.uk
Just as a single antibiotic cannot treat all infections, it may be that a variety of agents utilised in drug eluting stents will be necessary to treat restenosis
Keywords: methotrexate; restenosis; stents
Abbreviations: DES, drug eluting stents; PCI, percutaneous coronary intervention
| The first 150 words of the full text of this article appear below. |
With the introduction of drug eluting stents (DES) into routine percutaneous coronary intervention (PCI), many consider the battle against restenosis won. A more realistic viewpoint, perhaps, is that these are merely the early engagements in what will eventually turn out to be a longer war. The evidence base for sirolimus and paclitaxel eluting stents is impressive, with target vessel revascularisation < 5% at nine months in selected patients and lesions.12 One area of uncertainty is whether these two agents alone are sufficient to treat the wide variety of lesions found in day-to-day practice; just as a single antibiotic cannot treat all infections, it may be that a variety of agents will be necessary to treat restenosis. Another question is whether there will be room to further lower the restenosis rate (ideally to zero) in the "real world" where complex coronary artery lesions (long, diffuse, calcific, etc) are the norm rather
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