© 2004 by BMJ Publishing Group & British Cardiac Society
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ISCHAEMIC HEART DISEASE
Low molecular weight heparin to treat pulmonary embolism 
In a meta-analysis of 12 trials, low molecular weight heparin was associated with a non-significant decrease in recurrent symptomatic venous thromboembolism at the end of treatment (1.4% v 2.4%; odds ratio (OR) 0.63, 95% confidence interval (CI) 0.33 to 1.18) and at three months (3.0% v 4.4%; OR 0.68, 95% CI 0.42 to 1.09) compared to unfractionated heparin. Similar estimates were obtained for patients who presented with symptomatic pulmonary embolism (1.7% v 2.3%; OR 0.72, 95% CI 0.35 to 1.48) or asymptomatic pulmonary embolism (1.2% v 3.2%; OR 0.53, 95% CI 0.15 to 1.88). For major bleeding complications, the odds ratio favouring low molecular weight heparin (1.3% v 2.1%; OR 0.67, 95% CI 0.36 to 1.27) was also not significant. This suggests that low molecular weight heparin is probably a safer alternative for the treatment of pulmonary as well as deep vein
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