MINI-SYMPOSIUM

SOXF: redox mediators of vascular smooth muscle cell growth

Z G Jin, B C Berk

Center for Cardiovascular Research, University of Rochester, New York, USA

Correspondence to:
Correspondence to:
Bradford C Berk MD PhD
University of Rochester, Department of Medicine, Box MED, Rochester, NY 14642, USA; bradford_berk{at}urmc.rochester.edu

Keywords: oxidative stress; heat shock proteins; cyclophilin A; vascular smooth muscle; signal transduction; atherosclerosis

Abbreviations: Ang II, angiotensin II; CyPA, cyclophilin A; ERK, extracellular regulated signal kinase; HSP90, heat shock protein 90; PDGF, platelet derived growth factor; PPIase, peptidyl-prolyl cis-trans isomerase; ROS, reactive oxygen species; SOXF, secreted oxidative stress induced factors; VSMC, vascular smooth muscle cells

The first 150 words of the full text of this article appear below.

Oxidative stress and the production of intracellular reactive oxygen species (ROS), such as superoxide (O₂^.–), hydrogen peroxide (H₂O₂), and hydroxyl radical (OH^.), have been implicated in the pathogenesis of cardiovascular disease, in part by promoting vascular smooth muscle proliferation.^1–4 Within the vessel wall, ROS are generated by several mechanisms, including vascular NAD(P)H oxidases.^5,6 ROS formation can be stimulated by mechanical stress, environmental factors, platelet derived growth factor (PDGF), angiotensin II (Ang II), and low density lipoproteins.^7–9 Because many risk factors for coronary artery disease such as hyperlipidaemia, hypertension, diabetes, and smoking increase production of ROS, it has been suggested that changes in vessel redox state are a common pathway involved in the pathogenesis of atherosclerosis and vascular injury.^1,6,10

Several key findings support the concept that ROS contribute to vascular diseases through effects on vascular smooth muscle cells (VSMC). Initial studies in our laboratory demonstrated that ROS . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Free radicals and redox signalling in cardiovascular disease

A M Shah and K M Channon
Heart 2004 90: 486-487. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

• Satoh, K., Matoba, T., Suzuki, J., O'Dell, M. R., Nigro, P., Cui, Z., Mohan, A., Pan, S., Li, L., Jin, Z.-G., Yan, C., Abe, J.-i., Berk, B. C. (2008). Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation. Circulation 117: 3088-3098 [Abstract] [Full Text]  
• Shamaei-Tousi, A., Halcox, J. P., Henderson, B. (2007). Stressing the obvious? Cell stress and cell stress proteins in cardiovascular disease. Cardiovasc Res 74: 19-28 [Abstract] [Full Text]