MINI-SYMPOSIUM

Novel NAD(P)H oxidases in the cardiovascular system

K K Griendling

Correspondence to:
Correspondence to:
Dr Kathy K Griendling
Emory University, Division of Cardiology, 319 WMB, 1639 Pierce Drive, Atlanta, GA 30322, USA; kgriend{at}emory.edu

Keywords: NAD(P)H oxidase; Nox

The first 150 words of the full text of this article appear below.

In the past 10 years, an enormous amount of research has focused on the role of NAD(P)H oxidases in cardiovascular physiology and pathophysiology. Initially, investigators characterised these enzyme activities biochemically and functionally, but more recently, the molecular identification of a family of Nox (NADPH oxidase) proteins related to the respiratory burst NAD(P)H oxidase of neutrophils has led to an explosion of information about expression patterns, regulation, and functional significance of these enzyme complexes. Nox enzymes have been found to be involved in the regulation of vascular tone, smooth muscle growth, inflammatory responses, and matrix metalloproteinase activity. They have been implicated in hypertension, atherosclerosis, heart failure, diabetic vascular disease, and restenosis. In this article, the current status of the molecular basis for and the functional consequences of activation of these novel enzymes will be discussed.

The first Nox enzyme to be cloned and characterised was termed gp91phox (or Nox2), because it . . . [Full text of this article]

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