MINI-SYMPOSIUM

¹ Erasmus Medical Center, Thoraxcenter, Rotterdam, The Netherlands
² Universitair Medisch Centrum, Julius Centrum, Utrecht, The Nertherlands

Correspondence to:
Correspondence to:
Professor Patrick W Serruys
Thoraxcenter, Bd-406, Dr. Molewaterplein 40, 3015-GD Rotterdam, Netherlands; p.w.j.c.serruys@erasmusmc.nl

Abbreviations: ARTS, arterial revascularisation therapies study; CABG, coronary artery bypass graft surgery; CCS, Canadian Cardiovascular Society; MACCE, major cardiac and cerebrovascular events; RESEARCH, rapamycin-eluting stent evaluated at Rotterdam Cardiology Hospital

Keywords: drug eluting stents; angioplasty; restenosis; atherosclerosis; multivessel disease

In-stent restenosis and the need of repeat revascularisation remain the major limitations of coronary angioplasty for patients with multivessel disease.^1,2 Utilisation of drug eluting stents in this context is expected to have a major impact on the effectiveness of percutaneous treatment. Sirolimus eluting stent implantation has recently been shown to significantly reduce coronary restenosis, with zero angiographic restenosis^3,4 and persistent long term neointimal inhibition.⁴ Moreover, sirolimus eluting stents were proven to be as safe as bare metal stents at 30 days in a group of patients with acute coronary syndromes and a high frequency of multivessel disease.⁵ However, currently the effect of this device on long term outcomes of patients with multivessel disease is largely unknown.

The sirolimus eluting stent received Conformité Européenne mark approval in April 2002, since when it has been available for routine use in Europe. From 16 April 2002, it has been the policy of our . . . [Full text of this article]

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