EDUCATION IN HEART
Coronary disease
Diabetes and cardiovascular disease: the road to cardioprotection
Cardiology Department, Coimbra University Hospital, Coimbra, Portugal
Correspondence to:
Correspondence to:
Professor Pedro Monteiro
Cardiology Department, Coimbra University Hospital, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal; pfmonteiro@netcabo.pt
Keywords: diabetes; cardioprotection; preconditioning
| The first 150 words of the full text of this article appear below. |
Diabetes is a metabolic disease whose incidence and prevalence has significantly increased in recent decades, mainly because of an increase in type 2 diabetes, which represents almost 90% of all cases of diabetes. The World Health Organization estimates that, by 2025, there will be 300 million diabetic patients (5.4% of the world population). Older patients are most affected by diabetes, as the disease prevalence increases with age, at least up until 75 years. The progressive aging of the global population could explain about half of the predicted increase of diabetic patients in the near future.1
Macrovascular disease (coronary artery disease, stroke, and peripheral vascular disease) is responsible for the majority of morbidity and mortality associated with type 2 diabetes. In the UK prospective diabetes study (UKPDS),2 the 10 year risk of all macrovascular complications was four times that of microvascular complications. Coronary artery disease is the leading cause
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