© 2005 by BMJ Publishing Group & British Cardiac Society
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ISCHAEMIC HEART DISEASE
With bare metal stents, restenosis can still occur in up to a third of cases. How can this be treated? After pre-treatment with 600 mg of clopidogrel for at least two hours before intervention, all patients were randomly assigned to one of three treatment groups: sirolimus stent, paclitaxel stent, or balloon angioplasty (100 patients in each group). The incidence of angiographic restenosis was 44.6% (41/92) in the balloon angioplasty group, 14.3% (13/91) in the sirolimus stent group (p < 0.001 v balloon angioplasty), and 21.7% (20/92) in the paclitaxel stent group (p = 0.001 v balloon angioplasty). The incidence of target vessel revascularisation was 33.0% (33/100) in the balloon angioplasty group, 8.0% (8/100) in the sirolimus stent group (p = 0.001 v balloon angioplasty), and 19.0% (19/100) in the paclitaxel stent group (p = 0.02 v balloon angioplasty). The secondary analysis showed a trend towards a lower rate of angiographic
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