© 2005 by BMJ Publishing Group & British Cardiac Society
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ISCHAEMIC HEART DISEASE
N terminal pro-B-type natriuretic peptide (NT-proBNP) was measured in baseline serum samples from 1034 patients referred for angiography because of symptoms or signs of coronary heart disease. The rate of death from all causes was determined after a median follow up of nine years. At follow up, 288 patients had died. The median NT-proBNP concentration was significantly lower among patients who survived than among those who died (120 pg/ml, interquartile range (IQR) 50–318 pg/ml, v 386 pg/ml, IQR 146–897 pg/ml; p < 0.001). Patients with NT-proBNP concentrations in the highest quartile were older, had a lower left ventricular ejection fraction (LVEF) and a lower creatinine clearance rate, and were more likely to have a history of myocardial infarction, clinically significant coronary artery disease, and diabetes than patients with NT-proBNP concentrations in the lowest quartile. In a multivariable Cox regression model, the hazard ratio for death from any cause for the
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