© 2005 by BMJ Publishing Group & British Cardiac Society
SCIENTIFIC LETTER
Impact of asynchronous ventricular activation on pro-inflammatory cytokines and oxidative stress in paced patients
Cardiology Department, University Hospital of Heraklion, Crete, Greece
Correspondence to:
Correspondence to:
Professor Panos E Vardas
Cardiology Department, University Hospital of Heraklion, PO Box 1352, Stavrakia, Heraklion, Crete, Greece; cardio@med.uoc.gr
Accepted 13 September 2004
Abbreviations: AVA, asynchronous ventricular activation; IL-6, interleukin-6; LP, lipid peroxides; RAVP, right apical ventricular pacing; TNF
, tumour necrosis factor
Keywords: asynchronous ventricular activation; cytokines; lipid peroxides
| The first 150 words of the full text of this article appear below. |
Asynchronous ventricular activation (AVA), caused by right apical ventricular pacing (RAVP), results in the deterioration of both systolic and diastolic function.1,2 Chronic RAVP under DDDR pacing mode in patients with sick sinus syndrome revealed a detrimental effect on left ventricular fractional shortening, left atrium dilation, and myocardial blood flow.3,4
Furthermore, although the mechanism has not been fully elucidated, pro-inflammatory cytokines and oxidative stress have been shown, in both experimental and clinical studies, to affect the myocardium, compromising ventricular systolic performance.5
We hypothesised that these two latter factors are implicated in the functional and metabolic abnormalities in patients with AVA caused by RAVP. With this in mind we studied the concentrations of interleukin-6 (IL-6), tumour necrosis factor (TNF), and lipid peroxides (LP) in patients with sick sinus syndrome and a permanent dual chamber pacemaker during physiological and RAVP, as produced by AAIR and DDDR permanent pacing, respectively.
We enrolled consecutive
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