© 2005 by BMJ Publishing Group & British Cardiac Society
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ISCHAEMIC HEART DISEASE
Previous trials (for example, PROVE-IT) have demonstrated that lowering low density lipoprotein (LDL) cholesterol below currently recommended values is beneficial in patients with acute coronary syndromes. In the TNT (treating to new targets) study, a total of 10 001 patients with clinically evident coronary heart disease (CHD) and LDL cholesterol < 130 mg/dl (< 3.4 mmol/l) were randomly assigned to double blind treatment and received either 10 mg or 80 mg of atorvastatin per day. Patients were followed for a median of 4.9 years. The primary end point was the occurrence of a first major cardiovascular event, defined as death from CHD, non-fatal myocardial infarction, resuscitation after cardiac arrest, or fatal or non-fatal stroke. The mean LDL cholesterol concentrations were 77 mg/dl (2.0 mmol/l) during treatment with 80 mg of atorvastatin and 101 mg/dl (2.6 mmol/l) during treatment with 10 mg of atorvastatin. The incidence of persistent elevations in liver
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