© 2005 by BMJ Publishing Group & British Cardiac Society
MINI-SYMPOSIUM
Endothelial dysfunction and cardiovascular disease: the role of predictive adaptive responses
1 Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Southampton, UK
2 Liggins Institute, Auckland, New Zealand
Correspondence to:
Correspondence to:
Professor Mark Hanson
Centre for Developmental Origins of Health and Disease, University of Southampton, Level F (MP887), Princess Anne Hospital, Coxford Road, Southampton, S016 5YA, UK; m.hanson@soton.ac.uk
Keywords: endothelial dysfunction; cardiovascular disease
| The first 150 words of the full text of this article appear below. |
Cardiovascular disease remains a major cause of morbidity and mortality in developed societies. It is also an increasing problem in developing societies, especially those in which transitions are occurring—for example, the migration of young people from rural to urban environments or the increasing availability of fast food of high calorific content. It is clear that such rapid changes in the incidence of cardiovascular disease, in some instances within a generation, cannot be explained in purely genetic terms. This does not deny the role of genetic factors (for example, single nucleotide polymorphisms) which convey susceptibility to disease, but emphasises that additional environmental factors must also play a major role. This idea is of course not new, although for many years such environmental contributions to disease risk have been considered to be largely adult "lifestyle" factors such as smoking, diet, and physical activity level. However, the results of interventions aimed at reducing
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