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ISCHAEMIC HEART DISEASE
In > 45 000 patients, the addition of 75 mg clopidogrel < 24 hours after ST elevation myocardial infarction (STEMI), in addition to aspirin and reperfusion, was assessed. Treatment was to continue until discharge or up to four weeks in hospital (mean 15 days in survivors) and 93% of patients completed it. The two prespecified co-primary outcomes were: (1) the composite of death, reinfarction, or stroke; and (2) death from any cause during the scheduled treatment period. Comparisons were by intention to treat, and used the log rank method. Allocation to clopidogrel produced a highly significant 9% (95% confidence interval (CI) 3% to 14%) proportional reduction in death, reinfarction, or stroke (2121 (9.2%) clopidogrel v 2310 (10.1%) placebo; p = 0.002), corresponding to 9 (SE 3) fewer events per 1000 patients treated for about two weeks. There was also a significant 7% (95% CI 1% to 13%) proportional reduction in
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