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Published Online First: 13 September 2005. doi:10.1136/hrt.2005.066035
Heart 2006;92:8-10
Copyright © 2006 BMJ Publishing Group Ltd & British Cardiovascular Society

EDITORIAL

Depression and disability in coronary patients: time to focus on quality of life as an end point

D C Haas

Correspondence to:
Dr Donald C Haas
Mount Sinai School of Medicine, Cardiovascular Institute, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA; donald.haas@msnyuhealth.org


Depression in acute coronary syndrome patients may have prognostic implications beyond mortality

Keywords: coronary heart disease; depression; disability; quality of life

The first 150 words of the full text of this article appear below.

Substantial prospective, epidemiologic evidence now suggests that among patients admitted to the hospital for an acute coronary syndrome (ACS), those suffering co-morbid depression are at significantly increased risk for future cardiovascular morbidity and mortality.1–4 This appears to be true even for patients with mild depressive symptoms that do not meet full clinical criteria for major depression.5 Given the remarkable prevalence of depressive symptoms among patients with coronary disease (approximately 20–30%), the issue is far from trivial.6 However, why depression is a risk factor for poor prognosis is unclear. In many studies, depression is an independent predictor of poor outcomes, which has prompted several investigators to suggest that depression itself may be causally related to the poor prognosis observed in depressed ACS patients.7 Other studies have demonstrated that depression is no longer an independent predictor of outcomes when the severity of coronary disease is rigorously measured and adjusted for in the . . . [Full text of this article]


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