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Heart 2006;92:1694-1700; doi:10.1136/hrt.2005.072595
Copyright © 2006 BMJ Publishing Group Ltd & British Cardiovascular Society

EDUCATION IN HEART

Valve disease

Epidemiology and antibiotic treatment of infective endocarditis: an update

Bruno Hoen

Correspondence to:
Correspondence to:
Dr Bruno Hoen
Service de Maladies Infectieuses et Tropicales, University of Besançon Medical Center, F-25030 Besançon Cedex, France; bruno.hoen@univ-fcomte.fr

Keywords: antibiotics; infective endocarditis

The first 150 words of the full text of this article appear below.

The epidemiological profile of infective endocarditis (IE) has changed dramatically over the last few years.1 Once a disease affecting young adults with previously well-identified valve disease—mostly rheumatic disease—IE is now affecting older patients, a significant proportion of whom has no previously known valve disease and develop IE as the result of healthcare associated procedures.2


A CHANGING EPIDEMIOLOGY

Until the end of the 1970s, rheumatic valvulopathies and congenital cyanotic cardiopathies were the two most frequent predisposing factors for IE. Then, a few years after the effective eradication of rheumatic fever, post-rheumatic valvulopathies gradually disappeared. However, other predisposing factors emerged, such as intravenous drug use, valve prostheses, degenerative valve sclerosis, and invasive procedures at risk for bacteraemia, which resulted in nosocomial and health care-associated endocarditis.3 These changes had at least two consequences: (1) the absence of a reduction in the incidence of IE; and (2) major changes in the microbiological profile of IE. . . . [Full text of this article]


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