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ISCHAEMIC HEART DISEASE
To compare the clinical, angiographic, neurocognitive, and quality of life outcomes of off-pump coronary artery bypass surgery with conventional coronary artery bypass grafting (CABG) surgery using cardiopulmonary bypass, patients were randomised to conventional CABG surgery using cardiopulmonary bypass (n = 84) or off-pump coronary artery bypass surgery (n = 84), carried out by one surgeon. Angiographic examination was carried out at three months postoperatively. Neurocognitive tests were carried out at baseline and at six weeks and six months postoperatively. Graft patency was evaluated by angiography in 151 (89.9%) patients and was similar (about 93%) between the cardiopulmonary bypass and off-pump groups (risk difference –1%, 95% confidence interval (CI) –5% to 4%), with the off-pump group considered the treatment group. Patients in the off-pump group required fewer blood transfusions (1.7 units v 1.0 unit, p = 0.02), shorter duration of mechanical ventilation (7.7 h v 3.9 h, p = 0.03), and
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