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GENERAL CARDIOLOGY
Little data exist on the prevalence, incidence and prognostic value of ECG abnormalities in asymptomatic postmenopausal women. Denes et al looked at the ECGs of 14 749 women enrolled in the Women’s Health Initiative Study, all of whom were healthy postmenopausal women randomised to receive oestrogen and progestin or placebo. The Novacode criteria were used to stratify ECG abnormalities. End points included coronary heart disease (CHD) and cardiovascular disease (CVD) events.
Overall, there were 118 incident events among 9744 women with normal ECGs, 91 among those with minor abnormalities and 37 among those with major abnormalities. The incident annual CHD event rates per 10 000 women with absent, minor or major ECG abnormalities were 21 (95% CI 18 to 26), 40 (95% CI 32 to 49) and 75 (95% CI 54 to 104), respectively. The adjusted hazard ratios for CHD events were 1.55 for minor and 3.01 for major baseline
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