EDITORIALS
BNP: not just for heart failure
Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch Hospital, New Zealand
Correspondence to:
Professor M G Nicholls, Department of Medicine, Christchurch School of Medicine and Health Sciences, Riccarton Avenue, PO Box 4345, Christchurch, New Zealand; gary.nicholls@cdhb.govt.nz
| The first 150 words of the full text of this article appear below. |
Measurement of circulating natriuretic peptides has found a secure place in the diagnosis and management of patients with heart failure. In this issue of Heart, Khan and colleagues report that plasma levels of immunoreactive N-terminal pro-B-type natriuretic peptide (NTproBNP) provide prognostic information better than that given by the TIMI risk score in patients with ST-segment elevation myocardial infarction (STEMI) (see article on page 40).1 The paper adds significantly to an already impressive literature describing the response of circulating natriuretic peptides, especially the B-type peptides, to acute coronary syndromes (ACS) and their potential use as prognostic indicators.
Circulating levels of the natriuretic peptides (BNP, NTproBNP and atrial natriuretic peptide (ANP)) exhibit a substantial and sustained increase after ACS, although the magnitude and pattern of change differs between the peptides.2 What accounts for this response? Enhanced cardiac secretion of the peptides results probably from increased mechanical stretch of the
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- N-terminal pro-B-type natriuretic peptide is better than TIMI risk score at predicting death after acute myocardial infarction
- S Q Khan, P Quinn, J E Davies, and L L Ng
Heart 2008 94: 40-43.[Abstract] [Full Text] [PDF]
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Edwards, A. V. G., White, M. Y., Cordwell, S. J.
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