EDITORIALS
Exercise-induced ventricular dysfunction in hypertrophic cardiomyopathy: stunning by any other name?
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Correspondence to:
Drs Houman Ashrafian, and Hugh Watkins, Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU; houman.ashrafian@cardiov.ox.ac.uk
| The first 150 words of the full text of this article appear below. |
Hypertrophic cardiomyopathy (HCM) is a common cardiac genetic disorder with a prevalence of 1/500 and is caused principally by mutations in genes encoding proteins of the cardiac sarcomere (eg, β-cardiac myosin heavy chain and cardiac troponin T).1 Although of substantial scientific importance, HCM is best recognised for being the most common cause of sudden cardiac death (SCD) in the young, especially in young athletes, accounting for up to one-third of all such deaths in the US.2 HCM might be expected to impair exercise capacity, for example through left ventricular hypertrophy (LVH) and diastolic ventricular dysfunction; however, some HCM patients not only tolerate exercise well, but indeed excel athletically. This is surprising given that even HCM patients without LVH exhibit subtle systolic and diastolic abnormalities. Additionally, approximately one-third of HCM patients exhibit abnormal blood pressure (bp) responses during maximal treadmill exercise (ie, a flat blood pressure response, or a fall in
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Article
- Exercise-induced systolic dysfunction in patients with non-obstructive hypertrophic cardiomyopathy and mutations in the cardiac troponin genes
- K Sakata, H Ino, N Fujino, M Nagata, K Uchiyama, K Hayashi, T Konno, M Inoue, H Kato, Y Sakamoto, T Tsubokawa, and M Yamagishi
Heart 2008 94: 1282-1287.[Abstract] [Full Text] [PDF]
This article has been cited by other articles:
-
Sherrid, M. V., Wever-Pinzon, O., Shah, A., Chaudhry, F. A.
(2009). Reflections of inflections in hypertrophic cardiomyopathy.. J Am Coll Cardiol
54: 212-219
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
