Heart 2008;94:1264-1268
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The genetics of hypertrophic cardiomyopathy: Teare redux
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Correspondence to: Professor Hugh Watkins, Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK; hugh.watkins@cardiov.ox.ac.uk
Accepted 16 July 2008
| The first 150 words of the full text of this article appear below. |
In contrast to the challenges that frustrate the complete genetic delineation of complex common diseases (for example, type 2 diabetes mellitus or coronary disease),1–3 there has been extensive success in the delineation of highly penetrant loci in rarer disorders that conform to Mendelian inheritance.4 Linkage studies in multi-case, multi-generation families have identified more than 1300 of such causal genes. Hypertrophic cardiomyopathy (HCM) represents the first, and hence perhaps best known, example of an inherited cardiac disorder to be understood in this way and its study has epitomised the application of genetics to cardiovascular disease.5 6
A generation before any such genetic advances contributed to the understanding of HCM, Donald Teare’s now classic 1958 paper7 emphasised aspects of the disease that not only endure but resonate and inform today’s state-of-the-art genetic research. After his training at Gonville and Caius College, Cambridge, and at St George’s Hospital, the professor of forensic medicine at
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