REVIEWS

Left ventricular outflow tract obstruction in hypertrophic cardiomyopathy: past, present and future

S R Ommen¹, P M Shah², A J Tajik³

¹ Mayo Clinic, Rochester, Minnesota, USA
² Hoag Heart Valve Center, Newport Beach, California, USA
³ Mayo Clinic, Scottsdale, Arizona, USA

Dr Steve R Ommen, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; ommen.steve@mayo.edu

Accepted 16 July 2008

The first 150 words of the full text of this article appear below.

Fifty years ago, the first modern reports of what we now recognise as hypertrophic cardiomyopathy (HCM) were written by a surgeon, Sir Russell Brock,¹ and a pathologist, Donald Teare.² These classic papers stimulated an intense and sometimes controversial field of study, focused in large part on the characterisation of left ventricular outflow tract obstruction. Detailed invasive haemodynamic investigations highlighted the extraordinary dynamic nature of this new form of outflow obstruction, and numerous surgical therapies were proposed and abandoned. The introduction of echocardiography allowed investigators to determine the mechanism for obstruction—an adverse interaction between a hypertrophied septum and abnormal movement of the mitral valve towards the septum—but also showed that obstruction was not a universal feature of the disease. The focus of this article is to review the historical controversies surrounding left ventricular outflow tract obstruction in hypertrophic cardiomyopathy, and to discuss the modern approach to its assessment and treatment.

PRESENCE AND PREVALENCE OF OBSTRUCTION

As . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Hypertrophic cardiomyopathy: a 50th anniversary

Perry Elliott and William McKenna
Heart 2008 94: 1247-1248. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

• Kwon, D H, Smedira, N G, Popovic, Z B, Lytle, B W, Setser, R M, Thamilarasan, M, Schoenhagen, P, Flamm, S D, Lever, H M, Desai, M Y (2009). Steep left ventricle to aortic root angle and hypertrophic obstructive cardiomyopathy: study of a novel association using three-dimensional multimodality imaging. Heart 95: 1784-1791 [Abstract] [Full Text]  
• Ommen, S. R, Nishimura, R. A (2009). What causes outflow tract obstruction in hypertrophic cardiomyopathy?. Heart 95: 1725-1726 [Full Text]  
• Kaludercic, N., Reggiani, C., Paolocci, N. (2009). Genes, Geography and Geometry: The "Critical Mass" in Hypertrophic Cardiomyopathy. J. Mol. Diagn. 11: 12-16 [Abstract] [Full Text]