Heart 2008;94:1361-1363
FEATURED EDITORIAL
Genome scanning and cardiovascular disease
Professor E J Topol, Scripps Translational Science Institute, Scripps Genomic Medicine, 3344 N Torrey Pines Court, La Jolla 92037, 858-554-5708, California, USA; etopol@scripps.edu
| The first 150 words of the full text of this article appear below. |
At the end of 2007, Science recognised human genetic variation as the "breakthrough of the year".1 Beginning in April last year and extending through the current year, major advances have been made almost every week to unravel common DNA sequence variants that are incontrovertibly associated with common diseases. More than 50 diseases have now been reported, and many cardiovascular conditions are included in this avalanche of discoveries. There probably has been more progress in understanding the genomics of disease in the past year than for several previous decades in aggregate.
MAJOR INITIATIVES
The seemingly relentless and extraordinary progress in genomics of complex traits is an outgrowth of three major initiatives. First, the Human Genome Project accomplished its goal of sequencing the 3.1 billion base pairs of man, with the draft first announced in 20002 (fig 1). Second, the International HapMap project studied 271 subjects of diverse ancestry3 to break down
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