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Arrhythmic substrate

St George’s, University of London

Correspondence to:
Professor M Malik, Cardiac & Vascular Sciences, St George’s, University of London, Cranmer Terrace, London SW17 0RE, UK; marek.malik@btinternet.com

The first 150 words of the full text of this article appear below.

Although many advances have been made in the comprehension of pathophysiological details, our principal understanding of ventricular arrhythmia in ischaemic heart disease is still based on the classical concept of "arrhythmic triangle".^{1 2} It postulates that arrhythmia appears under a particular combination of proarrhythmic substrate, triggers, and modulators.

Most recent studies of this concept concentrated on both explanation and characterisation of arrhythmia-favouring modulators, ranging from advanced studies of cardiac autonomic status to abnormalities in repolarisation processes of ventricular myocytes.^3–5 Less attention has recently been given to electrocardiographic assessment of arrhythmic triggers,^{6 7} while practically all recent studies of proarrhythmic substrate utilised programmed ventricular stimulation,⁸ although its practical value now appears somewhat less strong than initially expected. Fairly little progress has been made in electrocardiographic non-invasive assessment of proarrhythmic substrate since the period of intensive investigations of signal-averaged electrocardiography.⁹ It is therefore pleasing that a new electrocardiographic technique is described by Elgarhi et . . . [Full text of this article]