EDITORIALS
Identifying patients with familial hypercholesterolaemia in primary care
1 Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London, UK
2 London IDEAS Genetics Knowledge Park, London, UK
Correspondence to:
Professor S E Humphries, University College London Medical School Centre for Cardiovascular Studies, 5 University Street, London WC1E 6JJ, UK; rmhaseh@ucl.ac.uk
| The first 150 words of the full text of this article appear below. |
In the current issue of Heart, Gray et al report the results of a pilot study to identify patients with familial hypercholesterolaemia (FH) in general practice (see article on page 754).1 Why is this important and how did they do it?
FH is a common disorder where subjects have markedly raised low-density lipoprotein-cholesterol (LDL-C), and consequently have premature coronary heart disease (CHD) and myocardial infarction. Studies carried out in the 1970s in the UK and the USA2 3 suggest that, if untreated, 50% of men with FH will have developed CHD by the age of 55 years and 50% of women by the age of 65 years (women show the same degree of elevation of LDL-C but are protected somewhat from the atherosclerosis until after the menopause). Thankfully, patients with FH are now well treated by statins and their overall standardised CHD mortality rate has fallen from 8.1
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Heart 2008 94: 754-758.[Abstract] [Full Text] [PDF]
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