EDITORIALS
Low-density lipoprotein and aortic stenosis
1 Northwestern University Feinberg School of Medicine, Chicago, USA
Correspondence to:
Nalini M Rajamannan, MD, Northwestern University Feinberg School of Medicine, 300 E Chicago, Tarry 12-717, Chicago, Illinois 60611, USA; n-rajamannan@northwestern.edu
| The first 150 words of the full text of this article appear below. |
With the decline of acute rheumatic fever, calcific aortic stenosis has become the most common indication for surgical valve replacement in the USA. In the past decade, Stewart and Otto1 2 have described the risk factors for calcific aortic stenosis, including lipids, hypertension, male gender, renal failure, and diabetes. Furthermore, these risk factors are parallel to those described for vascular atherosclerosis. For years this disease process was thought to be due to a degenerative phenomenon by which calcium attaches to the surface of the aortic valve leaflet. Initial models of experimental hypercholesterolaemia have demonstrated that initiating events in aortic valve disease are similar to those of vascular atherosclerosis. Over the past decade, there have been a growing number of studies evaluating human aortic valve specimens defining the cellular pathways important in this disease process. Studies from two independent laboratories, Mohler et al3 and Rajamannan et al,4 have shown that the
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Article
- Association between circulating oxidised low-density lipoprotein and fibrocalcific remodelling of the aortic valve in aortic stenosis
- C Côté, P Pibarot, J-P Després, D Mohty, A Cartier, B J Arsenault, C Couture, and P Mathieu
Heart 2008 94: 1175-1180.[Abstract] [Full Text] [PDF]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Drugs: cardiovascular system
-
Aortic valve disease
-
Hypertension
-
Echocardiography
-
Clinical diagnostic tests
- Relevant Article
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
