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Published Online First: 27 August 2008. doi:10.1136/hrt.2008.155507
Heart 2009;95:1-3
Copyright © 2009 BMJ Publishing Group Ltd & British Cardiovascular Society

FEATURED EDITORIAL

Thiazolidinediones and cardiovascular outcomes in type 2 diabetes

Sonal Singh1, Curt D Furberg2

1 Section on General Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
2 Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

Dr S Singh, Wake Forest University School of Medicine, One Medical Center Blvd, Winston-Salem, NC 27157, USA; sosingh@wfubmc.edu

The first 150 words of the full text of this article appear below.

Patients with type 2 diabetes experience high rates of comorbid conditions such as hypertension and dyslipidaemia that further compound their already increased risk of developing ischaemic heart disease (IHD). IHD and hypertension, in turn, represent conditions that are major precursors of congestive heart failure (CHF), adding to the cardiovascular disease (CVD) burden in this patient population. This is reflected in the reported estimate of IHD prevalence in diabetics (approximating 22%)1 and the reported 10-year incidence of CHF among elderly patients with newly diagnosed type 2 diabetes (exceeding 50%).2 The American Heart Association and the American Diabetes Association have also noted in a joint scientific statement paper that CVD contributes to more than three-quarters of all deaths in diabetic patients.3


 

The health benefits of treating hypertension with angiotensin-converting enzyme inhibitors4 and treating hyperlipidaemia with statins5 have been well established in clinical trials. The use of other preventive measures such . . . [Full text of this article]


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Thiazolidinediones and cardiovascular disease
Peter J Grant
Online, 4 Sep 2008 [Full text]

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