Heart 2009;95:861-865
FEATURED EDITORIAL
Update on dual antiplatelet therapy for percutaneous coronary intervention
The Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
Dr Abhiram Prasad, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; prasad.abhiram@mayo.edu
| The first 150 words of the full text of this article appear below. |
Platelet activation is central in the vascular response to percutaneous coronary intervention (PCI). In addition, patients with coronary artery disease (CAD), particularly those with an acute coronary syndrome (ACS), have pre-existing platelet hyper-reactivity. Together, these are among the factors that predispose to stent thrombosis (ST). Thus, dual antiplatelet therapy (DAT), which consists of aspirin and a thienopyridine, forms the cornerstone of pharmacotherapy following PCI with the goal of reducing ST, as well as ischaemic events related to the underlying CAD. Adherence to DAT, and the need for a longer duration of treatment, has become even more important for patients receiving drug-eluting stents (DES), as concerns have been raised regarding the increased risk of very late ST (>1 year) with the current generation of stents.1 Table 1 summarises the most recent guidelines on DAT following PCI which have been jointly published by the American College of Cardiology (ACC), American Heart Association
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