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GENERAL CARDIOLOGY
Standard treatment of acute pulmonary embolism (PE) consists of regimens involving anticoagulation therapy alone. Thrombolytic therapy (TT) may provide a mechanism for more rapid thrombus dissolution and improvement in pulmonary blood flow and may therefore offer benefit to certain patient groups, such as those presenting with features of cardiopulmonary compromise. However, previous studies have failed to demonstrate a clear mortality advantage for TT among patients presenting with acute PE, and data for the indications and benefit of TT in this setting are inconsistent. It remains unclear how these mixed reports have influenced the prevalence of TT in both academic and community hospital settings.
In order to deal with this knowledge gap Ibrahim and coworkers analysed a state-wide (Pennsylvania, USA) database involving 15 116 patients who had a primary diagnosis of PE. Patients with a prior diagnosis of major bleeding were excluded. Specifically, the prevalence of TT together with 30-day and
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