Editorials
Is C-reactive protein a prognostic marker after angioplasty?
First Cardiology Department, Athens University Medical School, Athens, Greece
Correspondence to:
Dr Dimitris Tousoulis, Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece; drtousoulis@hotmail.com
| The first 150 words of the full text of this article appear below. |
C-reactive protein (CRP), an acute phase reactant and a strong marker of inflammation, has been found repeatedly to be a strong predictor of future cardiovascular events1 and a marker of statin treatment in apparently healthy subjects without hyperlipidaemia.2 Recently, the Jupiter trial2 used CRP as the unique inflammatory marker to investigate the impact of rosuvastatin treatment on cardiovascular events. The study enrolled healthy men and women with low-density lipoprotein cholesterol levels of less than 130 mg/dl and high-sensitivity (hs) CRP levels of 2.0 mg/l or higher. Rosuvastatin reduced low-density lipoprotein cholesterol levels by 50% and hsCRP levels by 37%. Importantly, the decrease in CRP levels was accompanied by a significant reduction in the incidence of major cardiovascular events. As a result of the important role of inflammation in cardiovascular disease and the prognostic value of CRP, preprocedural measurement of CRP has been proposed to be a tool in identifying patients
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