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GENERAL CARDIOLOGY
Data from the GISSI-Prevenzione study (Lancet 1999;354:447–55) suggested that omega-3 fatty acids may have the ability to reduce death from cardiovascular causes, mainly through a reduction in sudden cardiac death (SCD). However, subsequent studies among patients with implantable cardiac defibrillators (ICD) failed to demonstrate any reduction in device therapy with supplemental fish oils, possibly owing to methodological limitations such as small sample size, poor patient adherence and high loss to follow-up. Furthermore, previous systematic reviews of fish oil therapy have been inconclusive but have not included some of the most recent data, such as the JELIS trial (Lancet 2007;369:1090–8).
Leon et al performed a systematic review of 12 randomised trials of fish oil supplementation, which included a total of 32 779 patients. The primary outcome of interest was the arrhythmic end point of appropriate ICD intervention and SCD. Secondary outcomes were all-cause mortality and
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