Education in Heart
Clinical PharmacologyFallacies in clinical cardiovascular trials
Correspondence to:
Correspondence to Professor Karl Swedberg, Department of Medicine, Sahlgrenska University Hospital/Ostra, 416 85 Göteborg, Sweden; karl.swedberg@gu.se
| The first 150 words of the full text of this article appear below. |
"The further you can look back, the longer you can look forward."Winston Churchill, Royal College of Physicians, 1944
Cardiovascular medicine has developed dramatically over the past 20–30 years, with major advances in the understanding and treatment of such diseases as coronary heart disease, cerebrovascular disease, hypertension, peripheral artery disease, and heart failure. Of major importance in this improved treatment are the many clinical trials and the advancement of evidence based medicine that these trials have documented. However, in this development not all trials have been successful and, in fact, the intervention in several trials has been associated with increased risk. Furthermore, the interpretation of trial outcomes has not always been correct and we know that history can bring about a different answer.
The intention with this article is to provide some examples of fallacies in cardiovascular trials that can improve our understanding in the design, conduct and
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