Heart 2009;95:1553-1555
Editorials
Remote ischaemic preconditioning: the current best hope for improved myocardial protection in cardiac surgery?
University Hospital Birmingham NHS Trust, Birmingham, UK
Correspondence to Professor R S Bonser, Cardiopulmonary Unit, Queen Elizabeth Hospital Edgbaston, Birmingham B15 2TH, UK; robert.bonser@uhb.nhs.uk
Accepted 28 April 2009
| The first 150 words of the full text of this article appear below. |
Ischaemic preconditioning has been recognised as a major cardioprotective phenomenon for many years.1 2 Cycles of non-lethal ischaemia and reperfusion applied to the heart before a potentially lethal ischaemic insult have the ability to reduce infarct size by >50%. More recently, it became apparent that the protection generated by this classical form of direct ischaemic preconditioning could be replicated when the non-lethal ischaemia was applied to one segment of the heart and the lethal ischaemia applied to a separate segment.3 Thereafter, it became established that the same protection could also occur even if the preconditioning ischaemic stimulus was applied completely distant from the target organ requiring protection—that is, transient ischaemia of a remote organ or limb could still generate protection for the organ being subsequently challenged by lethal ischaemia.4 There is now clinical evidence, suggesting that this remarkable remote ischaemic preconditioning (RIPC) phenomenon may represent a simple, inexpensive, easily applied method
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Heart 2009 95: 1567-1571.[Abstract] [Full Text] [PDF]
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