Heart 2009;95:98-99
EDITORIALS
Bone marrow cells to improve ventricular function
Department of Medicine, Division of Cardiology, Pneumology and Vascular Medicine, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany
Dr B-E Strauer, Department of Medicine, Division of Cardiology, Pneumology and Vascular Medicine, Heinrich-Heine-University of Düsseldorf, Moorenstr 5, 40225 Düsseldorf, Germany; strauer@med.uni-duesseldorf.de
| The first 150 words of the full text of this article appear below. |
Cardiac performance after myocardial infarction (MI) is compromised by ventricular remodelling, which represents a major cause of late infarct-related chronic heart failure and death. Clinical studies have shown recently that bone marrow mononuclear cells may restore damaged myocardium in humans1 2 with variable certainty.3 4 Stem cells have the important properties of self-regeneration and differentiational plasticity. Human bone marrow contains CD34-positive haematopoietic and CD34-negative mesenchymal stem cells and both these types of stem cells may contribute to heart muscle repair.
Clinical studies with direct intracoronary transplantation of bone marrow cells until now have been concerned mainly with three clinically relevant situations:
- treatment for acute MI1–6;
- treatment for old MI (
8 years, with heart failure)7;
- treatment for congestive heart failure (dilatative cardiomyopathy).6 8
The study in this issue of Heart by van Ramshorst et al9 focuses on important aspects of bone marrow cell-related therapy in chronic heart dysfunction: (a)
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- Effect of intramyocardial bone marrow cell injection on left ventricular dyssynchrony and global strain
- J van Ramshorst, D E Atsma, S L M A Beeres, S A Mollema, N Ajmone Marsan, E R Holman, E E van der Wall, M J Schalij, and J J Bax
Heart 2009 95: 119-124.[Abstract] [Full Text] [PDF]
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